Gut taste buds targeted to fight obesity
Washington: Targeting taste sensors in the gut may be a promising new strategy to control obesity, researchers say.
The gut "tastes" what we eat—bitter, sweet, fat, and savory—in much the same way as the tongue and through the use of similar signaling mechanisms.
The result is the release of hormones to control satiety and blood sugar levels when food reaches the gut.
The sensors, or receptors, in the stomach respond to excess food intake, and their malfunction may play a role in the development of obesity, diabetes, and related metabolic conditions.
Drs. Sara Janssen and Inge Depoortere, of the Translational Research Center for Gastrointestinal Disorders at the Catholic University of Leuven, Belgium, examine this possibility, offering insights into the latest research on the topic.
They say growing evidence suggests that obesity and related conditions might be prevented or treated by selective targeting of taste receptors on cells in the gut to release hormones that signal a feeling of fullness, thereby mimicking the physiological effects of a meal and fooling the body into thinking that it has eaten.
"The effectiveness of bariatric surgery to cause profound weight loss and a decrease in the prevalence of diabetes and other obesity-related conditions is not completely understood, but it may involve changes in the release of gut hormones," says Dr. Depoortere. "Targeting extraoral taste receptors that affect the release of hormones that control food intake may offer a new road to mimic these effects in a nonsurgical manner."
dditional studies are needed to show which gut taste receptors might be effective drug targets for the prevention and treatment of obesity and diabetes.
The study was recently published in the Cell Press journal Trends in Endocrinology ‘n’ Metabolism.
More from India
More from World
More from Sports
More from Entertaiment
- When Subramanian Swamy shocked people at a wedding!
- PM Modi speaks at Golden Jubilee celebrations of poet Dinkar’s works
- Mumbai: Diamond export company denies job to Muslim youth
- Vadodara: Policemen seen dancing with bar girls
- Coal scam: Naveen Jindal, Madhu Koda and others get bail
- Mirage 2000 fighter jet landing was part of capability demonstration: IAF
- One year of Modi govt: Arun Jaitley addresses press conference
- DNA: IAF Mirage 2000 fighter plane lands successfully on Yamuna expressway
- DNA: Osama documents show 'Indian brother in Madinah' financed al Qaeda
- Zee Media Exclusive: Kangana, Madhavan talk about their film 'Tanu Weds Manu Returns'
- ISIS executes Syrian fighter using anti-tank rocket launcher
- Zee Media Exclusive interview with Congress leader Kamal Nath
- Woman robbed at gunpoint inside Hyderabad ATM
- DNA: Harmful chemicals found in Maggi, Nestle India still in denial mode
- Columbia student takes rape-protest mattress to graduation
- Mumbai firm booked for denying Muslim MBA graduate job on religious grounds, probe ordered
- Jayalalithaa makes public appearance, meets Governor: As it happened
- New IPL rules could see Chennai Super Kings lose MS Dhoni
- `Piku` hits jackpot, does Rs 100 crore business worldwide
- Geelani's passport application incomplete, cannot be processed: MEA
- Lalu Yadav invites Jitan Ram Manjhi for joint fight against BJP, JD(U) upset
- Littering, defacement to be made punishable offence
- IPL 2015, Qualifier 2: CSK vs RCB - As it happened...
- CBSE Class 10 Results 2015 may not be announced today
- Kejriwal slams notification on LG's powers, says Modi running Delhi govt through back door
- India to soon have its own space shuttle!
- Check rajresults.nic.in: Rajasthan Board Class 12th results 2015 to be declared today
- Check JAC 12th Inter Arts Result 2015: JAC 12th Inter Arts Result 2015 declared on jac.nic.in
- WBBSE 10th Madhyamik Results 2015: West Bengal Board (wbbse.org & wbresults.nic.in) Class 10th Madhyamik Pariksha Results 2015 to be announced on May 22
- Don't know what will happen to my career, says Ranbir Kapoor