Washington: Elevated body mass index (BMI) is tied to increased risk of gallstone disease, especially in women, a new study has claimed. Researchers led by Dr Anne Tybjaerg-Hansen from Rigshospitalet, Copenhagen University Hospital in Denmark studied 77,679 participants from the general population, employing a Mendelian randomisation approach. Its a method using genetic variation to study the impact of modifiable risk factors as the cause of a disease. There were 4,106 participants who developed symptomatic gallstone disease during the 34 years of follow-up. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in US describe gallstones as pebble-like material, which can develop when there is excess cholesterol - accounting for 80 per cent of all gallstones - bile salts or bilirubin in bile stored in the gallbladder.
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