London: Bees make a protein called defensin-1 that they add to honey, which could one day be used to treat burns and skin infections and to develop new drugs that could combat antibiotic-resistant infections.
"We have completely elucidated the molecular basis of the antibacterial activity of a single medical-grade honey, which contributes to the applicability of honey in medicine," said Sebastian A.J. Zaat, researcher in medical microbiology at the Academic Medical Centre, Amsterdam.
"Honey or isolated honey-derived components might be of great value for prevention and treatment of infections caused by antibiotic-resistant bacteria," Zaat said.
To make the discovery, Zaat and colleagues investigated the antibacterial activity of medical-grade honey in test tubes against a panel of antibiotic-resistant, disease-causing bacteria. 3
They developed a method to selectively neutralise the known antibacterial factors in honey and determine their individual antibacterial contributions.
Ultimately, researchers isolated the defensin-1 protein, which is part of the honey bee immune system and is added by bees to honey.
After analysis, the scientists concluded that the vast majority of honey`s antibacterial properties come from that protein.
This information also sheds light on the inner workings of honey bee immune systems, which may one day help breeders create healthier and heartier honey bees, said a release of Academic Medical Centre.
"We`ve known for millennia that honey can be good for what ails us, but we haven`t known how it works," said Gerald Weissmann, editor-in-chief of FASEB Journal, which published these findings.
"Now that we`ve extracted a potent antibacterial ingredient from honey, we can make it still more effective and take the sting out of bacterial infections," he said.