Washington: Women who had metabolic syndrome before they started hormone therapy for menopause symptoms have a greatly increased risk of heart attack or dying of heart disease, a new analysis of the Women’s Health Initiative (WHI) trials has found.But women who didn’t have metabolic syndrome beforehand showed no increased risk.“Our findings emphasize the importance of assessing cardiovascular disease risk status when hormone therapy is considered for relief of menopausal symptoms,” wrote the WHI investigators who authored the study.Metabolic syndrome is a group of risk factors that occur together and increase the risk of heart disease, stroke, and diabetes. They include a large waistline, high blood pressure, high blood glucose or diabetes, high triglycerides, or low HDL—the “good cholesterol.” Obesity is the key feature, which predisposes women to the others.
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