Washington: Scientists have discovered the mechanism by which the environmental toxin arsenic leads to adverse health effects, including bladder cancer. "In a collaborative investigation we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated diseases, such as bladder cancer," said Margaret R. Karagas, professor in the Department of Community and Family Medicine at Dartmouth Medical School. "We provide important insight into the etiology of arsenic-induced disease, potentially relevant to the millions of people worldwide who are exposed to arsenic," she added.
Also, Karagas and colleagues found high levels of arsenic exposure associated with high levels of Hedgehog activity. These study results are published in Cancer Research, a journal of the American Association for Cancer Research. ANI
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