Washington: Scientists have proposed a new theory about how cancer cells grow and survive.
The finding could help researchers design better diagnostics and therapies to target high-risk cancer patients.
A large team of researchers at Thomas Jefferson University’s Kimmel Cancer Center conducted four new studies.
This new idea also explains why so many cancer patients say that “their cancer is eating them alive” – an accurate observation that has never been understood, the researchers say.
These four new studies provide evidence that tumor growth and metastasis is directly ‘fueled’ by normal supporting cells.
These supporting cells are called fibroblasts, and they produce the stroma (connective tissue) that surrounds tumor cells. As the cancer progresses, increasing numbers of these stromal cells eat themselves to provide recycled nutrients to tumor cells – leading to dramatic weight loss in patients.
They also found that without recycled nutrients provided by fibroblasts, tumor cells are more fragile and die. Based on this breakthrough, the researchers propose that available drugs (now on the market), which sever the ‘parasitic’ connection between tumor cells and fibroblasts, may be effective therapeutics.
“We think we have finally figured out how cancer really works – and this reverses 85 years of dogma, upon which current cancer research and therapy is based,” says the study’s senior investigator, Michael P Lisanti, MD, PhD, Chairman of Jefferson’s Department of Stem Cell Biology & Regenerative Medicine.
They have dubbed this finding “The Reverse Warburg Effect.”
“It’s amazing,” Dr Lisanti says.
“Much of what we know about cancer is backwards because cancer researchers used isolated tumor cells for most cancer studies. Now, when we put cancer cells back in their stromal environment, we see how cancer cells critically depend on fibroblasts for their survival.