Washington: Hebrew University researchers have discovered how the deadly malaria parasite evades the immune system, paving the way for the development of new approaches to cure this acute infection.More than a million people die each year of malaria caused by different strains of the Plasmodium parasite transmitted by the Anopheles mosquito.The medical world has yet to find an effective vaccine against the deadly parasite, which mainly affects pregnant women and children under the age of five.Upon entering the bloodstream, the Plasmodium parasite reproduces in the red blood cells and transports its proteins to their surface. These cells become sticky and cling to the walls of blood vessels, blocking them and damaging the human body. The immune system typically identifies these proteins as foreign and creates antibodies to fight the disease.The deadliest of the five Plasmodium strains is Plasmodium falciparum, which causes more than 90 percent of deaths associated with malaria. This sophisticated strain deceives the immune system by revealing only one protein encoded by one of the sixty genes at its disposal. While the immune system is busy fighting that protein, the parasite switches to another protein not recognized by the immune system, thus avoiding the antibody response and re-establishing infection.In research conducted at the Department of Microbiology and Molecular Genetics at the Institute for Medical Research Israel-Canada, and the Kuvin Center for the Study of Infectious and Tropical Diseases at the Hebrew University-Hadassah Medical School, Dr. Ron Dzikowski and research student Inbar Avraham revealed for the first time the genetic mechanism that enables a parasite to selectively express one protein while hiding other proteins from the immune system.By combining bioinformatic and genetic methods, the researchers identified a unique DNA sequence found in the regulatory regions of the gene family that encode for these surface proteins.
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