How red wine and green tea can prevent prostate cancer growth
Washington: Polyphenols, present in red wine and green tea inhibit cancer growth— a discovery that could lead to a major advance in the treatment of prostate cancer.
Researchers have explained how antioxidants in red wine and green tea produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth.
The finding is important because it may lead to the development of drugs that could stop or slow cancer progression, or improve current treatments.
"Not only does SphK1/S1P signaling pathway play a role in prostate cancer, but it also plays a role in other cancers, such as colon cancer, breast cancer, and gastric cancers," said Dr Gerald Weissmann, editor-in-chief of The FASEB Journal.
"Even if future studies show that drinking red wine and green tea isn`t as effective in humans as we hope, knowing that the compounds in those drinks disrupts this pathway is an important step toward developing drugs that hit the same target,” he added.
Scientists conducted in vitro experiments, which showed that the inhibition of the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway was essential for green tea and wine polyphenols to kill prostate cancer cells.
Then, mice genetically altered to develop a human prostate cancer tumour were either treated or not treated with green tea and wine polyphenols.
The treated mice showed reduced tumour growth as a result of the inhibited SphK1/S1P pathway.
To mimic the preventive effects of polyphenols, another experiment used three groups of mice given drinking water, drinking water with a green tea compound known as EGCg, or drinking water with a different green tea compound, polyphenon E.
Human prostate cancer cells were implanted in the mice and results showed a dramatic decrease in tumour size in the mice drinking the EGCg or polyphenon E mixtures.
"The profound impact that the antioxidants in red wine and green tea have on our bodies is more than anyone would have dreamt just 25 years ago. As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent ``health foods`` we know," added Weissmann.
More from India
More from World
More from Sports
More from Entertaiment
- Delhi: Taxi driver dies as BMW rams into car near IIT
- Train accident in Andhra Pradesh leaves many people dead
- UP Assembly Elections: Akhilesh Yadav releases party's manifesto
- DNA: Analyzing the harmful effects of selfies
- UP elections: Rajnath Singh's Son, Rita Bahuguna Joshi in BJP second list of candidates
- LIVE: Jallikattu Bill passed in Tamil Nadu Assembly; didn't use force on crowd, says Chennai Police Commissioner
- Naresh Agrawal breaks silence on leaving Akhilesh Yadav-led Samajwadi Party and joining BJP
- India vs England, 3rd ODI: MS Dhoni felicitated at Eden Gardens — VIDEOS INSIDE
- International Space Station – When, where and how to spot ISS
- Karnataka: Baby with four legs, two male sex organs born in Raichur