How white blood cells detect, destroy invaders
Washington: Scientists have identified a molecular receptor on the surface of white blood cells (WBCs) that is instrumental in destroying invading fungi.
The receptor Dectin-1 detects fungi and instructs WBCs whether to devour the invading pathogens or not, says David Underhill, associate professor in immunobiology at the Cedars-Sinai Medical Centre in Los Angeles.
The study is important because it moves scientists one step closer to understanding the mysteries of how our bodies mount an immune response to fight disease, reports the journal Nature.
In early stages of infection, WBCs patrol the body looking for invading pathogens. Dectin-1 recognises specific components of fungal cell walls, and alerts or "switches on" the immune cells to prepare to fight the infection, according to a Cedars-Sinai statement.
"Our lab has been studying Dectin-1, which directs white blood cells to eat and kill the fungi that they encounter directly, but to ignore soluble material sloughed off the fungal surface which does not pose an immediate threat," study co-author Helen Goodridge said.
"This is important because...anti-microbial defence responses are energy-intensive and destructive, and should only be used when absolutely necessary," Goodridge added.
More from India
More from World
More from Sports
More from Entertaiment
- Rajasthan: Gujjars revive reservation agitation, block rail track
- J Jayalalithaa sworn-in as Chief Minister of Tamil Nadu
- Dr Subhash Chandra Show: Aspiring for more than what you have!
- ISIS to buy first nuclear weapon from Pak?
- Mumbai: CCTV captures assailant with gun at Film City
- Mathura SSP receives death threat letter, message for PM Modi
- BJP now central pole of Indian politics: Arun Jaitley
- Maharashtra FDA sends Maggi noodles for lab testing
- Watch: Fast N Facts @ 7:30pm
- Haridwar: Hotel Radisson Blu sealed for polluting Ganga
- Reservation issue: Police register case against Bainsla, 20 others
- Delhi: Two killed in road accident in New Ashok Nagar
- Girl in Punjab's Pathankot quit studies for fear of eve-teasing
- Zee Media exclusive chat with 'Welcome to Karachi' cast
- Zee Media exclusive interview with Haryana CM Manohar Lal Khattar
- Goa Board SSC Exam Results 2015 announced
- ISIS close to buying nuclear weapon from Pakistan?
- Manohar Parrikar visits forward areas along LoC, reviews security situation
- Credibility of Prime Minister's Office restored by BJP, says Arun Jaitley
- ISIS justifies raping slave girls, says Michelle Obama is 'worth $40'
- IPL 2015 Final: Mumbai Indians vs Chennai Super Kings - Preview
- 'Unhappy' Celina Jaitley asks Sunny Leone to move out?
- Arvind Kejriwal to highlight AAP govt's 100 days work on Monday
- CBSE Results 2015: 10th board exam results to be declared on May 27
- BJP's plan for one-year celebration: 200 big rallies, 5,000 public meetings
- IPL 8 Final: We need to be at our best against Mumbai, says Michael Hussey
- Heatwave leaves 153 dead in Telangana, Andhra Pradesh
- Heatwave kills 223 in AP, Telangana, Chandrababu Naidu announces compensation; Delhi records hottest day
- 'Tanu Weds Manu Returns' starts on a good note at the Box Office!
- CBSE Results 2015: 12th board exam results to be declared on May 25