Lack of enzyme creates skewed response to fear
Washington: Do you run away when you should stay or stay when you should run away? If so, an enzyme deficiency might be to blame, a US medical study suggests.
Mice lacking a certain enzyme due to genetic mutation develop a topsy-turvy response to fear. For instance, they may show defensive behaviour, biting or tail rattling, in the presence of plastic bottles.
However, in the presence of real danger, these mice are found less cautious or defensive than their siblings, the International Journal of Neuropharmacology reports.
"Our findings suggest that monoamine oxidase A (moA) deficiency leads to a general inability to appropriately assess contextual risk," said senior study author Jean C. Shih, professor of pharmacology at the University of Southern Californa.
MoA is the main enzyme in the brain that breaks down neurotransmitters such as serotonin, norepinephrine and dopamine, which have been shown to contribute to the "fight or flight" impulse by raising heart rates and increasing blood and oxygen flow, according to the study.
This study, currently only conducted on mice, is among the first to clarify that perceived aggressiveness may have been an inability to properly adapt and respond to environmental cues.
"Mice without monoamine oxidase A exhibited a distinct inability to attune their response to the situation," said Sean Godar, post-doctoral research associate at Southern California and study co-author.
More from India
More from World
More from Sports
More from Entertaiment
- Zee Media Exclusive: Kangana, Madhavan talk about their film 'Tanu Weds Manu Returns'
- DNA: Harmful chemicals found in Maggi, Nestle India still in denial mode
- CM Kejriwal shortlists 39 'unwanted' IAS officers in Delhi
- Rajasthan: Gujjars revive reservation agitation, block rail track
- DNA: Modi-led NDA govt's hits and misses in one year
- Zee Media Exclusive interview with Congress leader Kamal Nath
- J Jayalalithaa sworn-in as Chief Minister of Tamil Nadu
- Mumbai: One injured in shootout at Film City
- ISIS to buy first nuclear weapon from Pak?
- Mumbai: CCTV captures assailant with gun at Film City
- Dr Subhash Chandra Show: Aspiring for more than what you have!
- BJP now central pole of Indian politics: Arun Jaitley
- Zee Media Exclusive chat with 'Tanu Weds Manu Returns' cast Kangana, Madhavan
- Maharashtra FDA sends Maggi noodles for lab testing
- Mathura SSP receives death threat letter, message for PM Modi
- IPL 2015, Qualifier 2: CSK vs RCB - As it happened...
- India to soon have its own space shuttle!
- PM Narendra Modi graces Digvijay Singh's son wedding reception
- Rahul Gandhi to pressurise govt to act on one-rank-one-pension issue
- Goa Board SSC Exam Results 2015 announced
- ISIS close to buying nuclear weapon from Pakistan?
- CBSE 12th Results 2015: CBSE Board Cbse.nic.in & cbseresults.nic class 12th XII board exam Results 2015 date announced
- Manohar Parrikar visits forward areas along LoC, reviews security situation
- Businessman shot next to Amitabh Bachchan's shooting location in Mumbai Film City
- There will be no delay in appointing CIC, CVC: Jitendra Singh
- Credibility of Prime Minister's Office restored by BJP, says Arun Jaitley
- ISIS justifies raping slave girls, says Michelle Obama is 'worth $40'
- CBSE Board 10th Results 2015: Cbse.nic.in & Cbseresults.nic class 10th X board exam results 2015 date announced
- LIVE SCORE: 1st Test, Day 2 - England vs New Zealand
- Arvind Kejriwal to highlight AAP govt's 100 days work on Monday