Toronto: Scientists have found that a protein shown to function in the liver has a key role in human menstrual cycle and may also play a crucial role in pregnancy. According to researchers at the University of Montreal in Canada, mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas. The researchers then showed that Lhr-1 was present in the human uterus and the essential processes related to the success of early gestation. "We previously showed that Lrh-1 is essential for ovulation. Our newest studies have revealed that it plays an important role in the uterus, raising the possibility that Lrh-1 deficiency contributes to human gestational failure," said lead author Bruce Murphy, of the university`s Animal Reproduction Research Centre.
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