Washington: Researchers have discovered that a gene thought to be associated with cancer development can be a tumour suppressor gene in mice.Understanding which genes are involved in spreading cancer could lead to future therapies. "For cancer to spread, some genes are activated, while others that would prevent cancer growth are prevented from doing their jobs. The cancer research community has thought that the gene p120, falls into the latter category," said Douglas Stairs, assistant professor of pathology, who completed this research at University of Pennsylvania and is now at Penn State College of Medicine.
"Some immune cells help the body get rid of the cancer cells, while other immune cells help tumours to form. When p120 was absent, tumour promotion through the immune system was activated. The mice produced the bad types of immune cells." Researchers learned through further investigation that these "bad" immune cells traveled to the esophagus and improperly activated fibroblasts. Fibroblasts are cells that create the support structure for tissues. They are most noticeably activated when tissue damage occurs and scarring is a result of the fibroblast cells activating. Fibroblasts are also activated in cancer patients. By improperly activating the fibroblasts, the immune cells were able to stay active longer than normal. "Each feeds off the other," said Stairs. "It creates an environment that is very permissive for cancer development," added Stairs. The study has been published in the journal Cancer Cell. ANI
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