Mixing right cocktail of proteins can help build better malaria vaccine
Washington: Researchers including an Indian-origin scientist have suggested that that a cocktail of AMA1 proteins from only a few different strains can overcome major limitations of an earlier designed version of AMA1-based malaria vaccines.
A team led by led by Sheetij Dutta, from the Walter Reed Army Institute of Research, USA, focused on a protein called AMA1 needed by the Plasmodium falciparum parasite to invade blood cells and cause disease.
The challenge with the malaria parasite in general and its AMA1 surface protein in particular is that both exist as multiple strains. Using AMA1 in a vaccine readies the human immune system for subsequent encounters with the parasite, but when such a vaccine was previously tested in humans, it was effective mostly against one particular P. falciparum strain.
To explore the potential for a more broadly protective vaccine, the scientists tested different cocktails of AMA1 from different parasite strains for their ability to elicit a diverse range of antibodies that are active in parasite inhibition assays.
They confirmed that a cocktail of AMA1 proteins from three different parasite strains was better than one or two, and one they call Quadvax, which contained AMA1 proteins derived from four different strains, led to an antibody response that was broader than the sum of strain-specific antibodies elicited by the four individual strains.
Moreover, Quadvax-elicited antibodies inhibited a range of parasites, including many strains that were different from those in the Quadvax mix. In different laboratory tests, Quadvax-induced antibodies inhibited the growth of 26 different parasite strains, and the scientists suggest that "the combination of four AMA1 variants in Quadvax may be sufficient to overcome global AMA1 diversity".
The study is published in journal PLOS Pathogens.
More from India
More from World
More from Sports
More from Entertaiment
- Street food in Delhi contains high levels of faecal matter
- Watch: ISIS prisoner digging his own grave
- 50 percent refund on Tatkal ticket cancellation
- UP: Govt to distribute free sanitary napkins to all girls in school
- Delhi HC turns down plea challenging LG Jung's authority
- DNA: Blow to Kejriwal, Delhi High Court backs LG
- IIT Madras bans Dalit students forum for 'criticising' PM Modi
- DNA: Exploitation of migrant workers in Qatar
- Radioactive nuclear medicine leak detected at Delhi's IGI Airport
- IIT Madras row: Smriti Irani hits back, challenges Rahul Gandhi to a debate
- MHA notification: SC issues notice to Delhi govt
- Railways may hike AC class fares from June 1, 2015
- Protests outside IIT-Madras against ban on students' group
- Aapke Sitare: Astro prediction for May 29, 2015
- Special: Heart-wrenching tales of elderly people in old age homes
- Delhi HC backs LG, turns down plea challenging Jung's authority
- WB Class 12 (HS) Result 2015 declared on wbresults.nic.in, wbchse.nic.in
- No radioactive leak at IGI airport, say AERB and Delhi govt
- Log on to wbresults.nic.in, wbchse.nic.in for WB Class 12 (HS) Result 2015 WBCHSE
- Twitter war over IIT Madras row: Smriti Irani challenges Rahul Gandhi to debate over any issue, anywhere
- Bihar board 12th Arts result to be declared today soon
- BSEB (biharboard.ac.in & biharboard.bih.nic.in): Bihar board 12th Arts result to be declared tomorrow on May 30
- Dangerous levels of toxins in Delhi's air as heat and dust intensify
- Maggi noodles controversy: Case to be filed against Nestle in UP today
- US formally removes Cuba from terror blacklist in landmark move
- Top 5 places to eat in Delhi University's campuses
- Arrival of Monsoon over Kerala delayed by 2-3 days: Met Department
- Govt committed to One Rank, One Pension: PM Narendra Modi
- Log on to ahsec.nic.in: AHSEC 12th Result 2015 to be announced today at 10 am
- If Congress was pro-poor, why does poverty still exist in India, asks PM Narendra Modi