London: Sceintists are developing a nano-sized drug particle for organ transplant patients to eliminate its harmful side-effects, reveals a study.The drug cyclosporine (CsA) is widely used in transplant operations and helps prevent the patient`s body rejecting the organ, but it can also cause adverse reactions, especially damaging kidneys and liver.The gap between a safe, effective and a toxic dose is extremely narrow, but the University of Strathclyde scientists have found a way of capturing CsA in very small amounts, the Journal of Biomedical Nanotechnology reported.The new system enables nanoparticles of the drug to be delivered orally so that the strength of the dose can be maintained, but at a level and in a form which spares kidneys from damage, said a university statement."CsA is very useful in transplants and treating conditions such as arthritis, lupus and some forms of diabetes, but we need to address the risks it can present to the kidney and liver," said Ravi Kumar, professor at the Strathclyde Institute of Pharmacy and Biomedical Sciences, who led the research.
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