London: Scientists from the University of Wisconsin-Madison have discovered a key anti-ageing enzyme that stops our cells from decaying.
The researchers found under reduced-calorie conditions, levels of Sirt3 increased altering metabolism and resulting in fewer free radicals produced by mitochondria.Signs of free radical damage are skin that is leathery, or wrinkled and sagging, and stiffness in the joints.Smoking, sunbathing, fried food, infections and stress can all produce excess free radicals. However, green leafy vegetables and whole grain bread contain antioxidants that can neutralise them.“This is the strongest and most direct link that caloric restriction acts through mitochondria,” Prolla said.Sirt3 is one of seven enzymes in the sirtuin family that appear to have a wide-ranging impact on cell fate and physiology.However, the new study provides ``the first clear evidence that sirtuins have anti-aging effects in mammals.``Understanding the molecular basis of how the sirtuin enzymes work may ultimately lead to the development of drugs that activate the pathways of enzymes like Sirt3 to slow down the process of ageing.The study has been published in the journal Cell. ANI
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