London: Loss of stem cells during chemotherapy or radiation therapy is the main side effect for human cancer patients, leading to anaemia, appetite and weight loss. But a new discovery could change that soon.The loss of adult stem cells is particularly dangerous, as they are the ones responsible for making new blood and intestine cells. Scientists have long known that during cancer therapy, the tumour suppressor p53 is activated, which leads cells to stop dividing, go into hibernation and undergo a programmed cell death called apoptosis.
“If you can suppress Puma function, you can rescue a lot of the adult stem cells that would otherwise be lost after the accumulation of DNA damage such as during cancer therapy,” he added.The team published its findings in this week’s advance online issue of the journal Nature Cell Biology. ANI
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