Washington: Researchers have identified infection-fighting and inflammation-suppressing functions for a gene which is associated with human autoimmune disease.The discovery by the University of Minnesota researchers, centered on a gene known as PTPN22, could set into motion new treatment approaches for autoimmune diseases like lupus, rheumatoid arthritis and type 1 diabetes. The key to these advances may lie with a better understanding of how a variant of PTPN22, known as a "risk variant," impacts autoimmune disease development and the behaviour of myeloid cells that act as the body`s "first responders."In launching their latest research project, University of Minnesota Center for Immunology researchers set out to determine how PTPN22 could regulate immune system function in health and disease.
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