Washington: A novel therapeutic approach in which key regions of the dengue genome essential for viral replication are targeted and silenced, can prevent dengue virus from reproducing in humans.Pei-wen Xie, Yu Xie, Xiu-juan Zhang, Hai Huang, Li-na He, Xue-jun Wang, and Sheng-qi Wang, Beijing Institute of Radiation Medicine and Second Artillery General Hospital, Beijing, and Central South University, Changsha, China, identified multiple regions in the dengue virus genome that have maintained the same nucleic sequence over long periods of evolution.These highly conserved regions are ideal targets for antiviral drug development as they are unlikely to mutate and allow the virus to develop drug resistance.
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