New screening strategy introduced to develop possible drug candidates

Last Updated: Monday, December 23, 2013 - 15:03
Pic Courtesy:

Washington: Scientists have developed a new drug-discovery strategy, which will help them in rapidly selecting chemical compounds that will have a desired effect on cells.

Researchers from the Scripps Research Institute (TSRI) has also tried to highlight how these compounds will work.

Scientists have identified a compound that shows promise for treating obesity-linked diabetes by using the innovative technique, and were able to identify the fat-cell enzyme that the compound inhibits.

The strategy uses the increasing availability of special libraries of related compounds that act as inhibitors of entire enzyme classes.

The researchers have used a set of compounds, recently synthesized by Cravatt's laboratory, that tend to inhibit serine hydrolases.

The researchers have been able to use combined phenotypic screening and target-identification approach to quickly discover, characterize and carry out preclinical tests of a potential new drug for obesity-linked diabetes.

The study was published an advance online issue of Nature Chemical Biology.


Download the all new Zee News app for Android and iOS to stay up to date with latest headlines and news stories in Politics, Entertainment, Sports, Technology, Business and much more from India and around the world.

First Published: Monday, December 23, 2013 - 15:03

More from zeenews

comments powered by Disqus