London: Suppressing activity of common intestinal bacteria reduces tumour growth, a new American study has found.The study, led by researchers at the University of California, San Diego School of Medicine, has appeared in the journal Nature Medicine.
Specifically, Raz and his co-authors found that mice with an engineered mutation that closely mimics FAP in humans leaves the mice notably vulnerable to inflammatory factors produced by ordinary bacterial activity. The constant inflammation enhances expression of an oncogene called c-Myc. Very quickly, the mice develop numerous tumours in their intestines and typically do not survive past six months of age.In humans, FAP can be equally devastating. It is a genetic condition in which patients at a young age begin to develop hundreds to thousands of polyps in their intestine. By age 35, 95 percent of individuals with FAP have polyps. The polyps start out benign, but ultimately become malignant without treatment. Current treatment essentially consists of prophylactic surgery -- removal of the polyps before they turn cancerous. Raz said: "Right now, people with FAP don`t have many options."They develop the cancer relatively early in life and the only treatment is surgery, often a total colectomy - the removal of the entire colon. And that still doesn`t preclude the possibility of developing tumors elsewhere in the body."That`s why the second part of the study was especially encouraging, Raz said. When researchers administered a protein enzyme called extracellular signal-related kinase or ERK, it appeared to suppress intestinal turmorigenesis in the mice, causing cancer proteins to degrade more rapidly and increasing the survival time of the mice. If the inhibiting enzyme, which is currently undergoing clinical trials elsewhere, proves to be safe and effective, researchers say it eventually could provide FAP patients with another option other than surgery.Raz said: "This is a clear case of nature and nurture in molecular biology."Nature is the host, who in some cases is going to be genetically predisposed to develop certain diseases. Nurture is the environment, which in this case is bacterial activity and its effects. The mechanism for what`s happening here with these mice and tumor growth is very clear. We know what we want and need to do." ANI
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