Washington: By the time we reach our 40s, we begin to lose muscles and by age 80, up to a third of the muscles may have disappeared. It``s an inevitable process of ageing called sarcopenia. But why does it happen and can it be stopped? A new study at The University of Texas Health Science Centre (UTHSC), San Antonio, has provided some answers. The study, conducted in mice with accelerated muscle loss, found less protection from antioxidants and more damage from oxidative stress results in impairment to cells`` energy centres (powerhouses) called mitochondria, which slowly leads to death of muscle cells.
He compared mitochondria from these mice and normal mice and found reduced function of the energy centres in the enzyme-deficient mice. This contributed to more cell death and muscle atrophy in the rodents. "As a result, their muscles were a lot smaller and weaker," Van Remmen said. If a muscle-preserving therapy is one day developed, future generations of young men will be able to keep their muscle shirts a bit longer. ANI
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