New way to treat chronic inflammation in diseases identified
Washington: Researchers have discovered a new mechanism to block inflammation in Alzheimer`s, Atherosclerosis and Type-2 Diabetes, without crippling the immune system.
The study conducted by the researchers at NYU Langone Medical Center suggests a common biochemical thread to multiple diseases and gives way to a new class of therapies that could treat chronic inflammation in these non-infectious diseases.
When the body encounters a pathogen, it unleashes a rush of chemicals known as cytokines that draws immune cells to the site of infection and causes inflammation.
Particulate matter in the body, such as the cholesterol crystals associated with vascular disease and the amyloid plaques that form in the brain in Alzheimer`s disease, can also cause inflammation but the exact mechanism of action remains unclear.
Researchers previously thought that these crystals and plaques accumulate outside of cells, and that macrophages-immune cells that scavenge debris in the body-induce inflammation as they attempt to clear them.
"We`ve discovered that the mechanism causing chronic inflammation in these diseases is actually very different," says Kathryn J. Moore, PhD, senior author of the study and associate professor of medicine and cell biology, Leon H. Charney Division of Cardiology at NYU Langone Medical Center.
The researchers found that particulate matter does not linger on the outside of cells. Instead, a receptor called CD36 present on macrophages draws the soluble forms of these particles inside the cell where they are transformed into substances that trigger an inflammatory response.
The resulting insoluble crystals and amyloid damage the macrophage and trigger a powerful cytokine, called interleukin-1B, linked to a chronic inflammatory response."
These findings hold exciting clinical implications. When the researchers blocked the CD36 receptor in mice with atherosclerosis (in which cholesterol thickens the arteries), the cytokine response declined, fewer cholesterol crystals formed in plaques, and inflammation decreased. Consequently, atherosclerosis also abated.
Other less-targeted strategies to control inflammation may hamper the immune response, but the CD36 strategy spares certain cytokines to fight off pathogens, while blocking CD36`s ability to trigger interleukin-1B.
The study was published Nature Immunology.
More from India
More from World
More from Sports
More from Entertaiment
- Dr Subhash Chandra Show: Aspiring for more than what you have!
- ISIS to buy first nuclear weapon from Pak?
- Mumbai: CCTV captures assailant with gun at Film City
- Mathura SSP receives death threat letter, message for PM Modi
- BJP now central pole of Indian politics: Arun Jaitley
- Reservation issue: Police register case against Bainsla, 20 others
- Watch: Fast N Facts @ 7:30pm
- Zee Media exclusive chat with 'Welcome to Karachi' cast
- Zee Media exclusive interview with Haryana CM Manohar Lal Khattar
- Haridwar: Hotel Radisson Blu sealed for polluting Ganga
- Girl in Punjab's Pathankot quit studies for fear of eve-teasing
- Special: Furious over rising water crisis, people take to the streets
- UP Minister allegedly threatens, abuses Gonda businessman
- Manali: Heavy corruption found in environmental taxes
- Couple in Bihar asked to pay Rs 50,000 as 'tax' for inter-caste marriage
- IPL 2015 Final: MI vs CSK - As it happened...
- IPL 8 Final: We need to be at our best against Mumbai, says Michael Hussey
- Heatwave leaves 153 dead in Telangana, Andhra Pradesh
- Heatwave continues in North India; death toll in Andhra Pradesh, Telangana more than 400
- Heatwave kills 223 in AP, Telangana, Chandrababu Naidu announces compensation; Delhi records hottest day
- CBSE.nic.in 12th XII Results 2015: CBSE Board (cbseresults.nic.in) Class 12th XII Exam Results 2015 to be announced on May 25
- 'Tanu Weds Manu Returns' starts on a good note at the Box Office!
- CBSE 12th Result 2015 to be announced on Monday
- Death threat to PM Narendra Modi ahead of Mathura rally sends police into tizzy
- Organisation demands re-examination of AIPMT 2015
- Standoff with LG: Arvind Kejriwal calls emergency session of Delhi Assembly
- Kejriwal completes 100 days in office, AAP says centre 'shadow boxing' over row with LG
- CBSE Class 12th Board Results 2015 to be announced on Monday, May 25
- IPL 2015 final: Mumbai Indians thrash Chennai Super Kings by 41 runs to lift second title
- Top 5 shopping destinations in Delhi!