Washington: Scientists at the University of Michigan Comprehensive Cancer Centre have discovered a novel way of targeting breast cancer cells that are resistant to current treatments.They have identified a receptor called, CXCR1, on the cancer stem cells, which triggers growth of stem cells in response to inflammation and tissue damage.
Mice treated with repertaxin or the combination of repertaxin and chemotherapy had dramatically fewer cancer stem cells than those treated with chemotherapy alone. In addition, repertaxin-treated mice developed significantly fewer metastases than mice treated with chemotherapy alone."These studies suggest that important links between inflammation, tissue damage and breast cancer may be mediated by cancer stem cells," Wicha said."Furthermore, anti-inflammatory drugs such as repertaxin may provide a means of blocking these interactions, thereby targeting breast cancer stem cells," Wicha added. The study appears in Journal of Clinical Investigation.ANI
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