Washington: In what could benefithumans in the future, scientists claim to have found a way tosignificantly reduce atherosclerosis in rodents which doesn`tinvolve lowering cholesterol or eliminating any other obesityrelated problem.Atherosclerosis is the process through which fattysubstances, such as cholesterol and cellular waste productsaccumulate in the lining of arteries. Those buildups, calledplaques, reduce blood flow through artery and can contributeto heart attack, stroke and even gangrene.
"With the current epidemic of obesity and diabetes,people sometimes forget that it`s the blockages in thearteries that really kill people"We`ve made progress using statin drugs, for example,that lower cholesterol and fight plaque buildup, but a lot ofpeople who take statins still die from cardiovascular disease.We need better therapies."It may be possible, for example, to take macrophagesout of humans, inhibit fatty acid synthase in those cells, andthen infuse the macrophages back into the same person. "Fromwhat we`ve observed in mice, we`ll hypothesize that approachmight prevent or interfere with plaque buildup in people," thescientists said.PTI
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