Washington: An anti-depressant developed over 40 years ago can blunt and even reverse the muscle enlargement and weakened pumping function associated with heart failure, research says.
"Our study helps describe heart failure as a vicious chemical circle of stimulant norepinephrine overload and breakdown, and it offers a disease blueprint with monoamine oxidase-A as the target for drugs similar to clorgyline to rein in the disease," says senior study investigator and cardiologist Nazareno Paolocci. Notable side-effects from clorgyline, Paolocci says, include insomnia and agitation, or high blood pressure, said a Johns Hopkins release. IANS
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