Washington: Flavonoids in orange juice neutralize the oxidative and inflammatory stress generated by high-fat, high-carb meals and help prevent blood vessel damage, claims a new study. Free radicals, or reactive oxygen species, are known to induce inflammation in blood vessel linings and contribute to the risk of heart attack and stroke. In the new study, University at Buffalo endocrinologists say the potent preventative effect of orange juice likely is linked to its heavy load of the flavonoids naringenin and hesperidin, which are major antioxidants.
"These data emphasize that a high-fat, high-carbohydrate meal is profoundly and rapidly proinflammatory, and that this process occurs at the cellular and molecular level," says Paresh Dandona, MD, UB distinguished professor of medicine, director of the Diabetes-Endocrinology Center of Western New York at Kaleida Health and senior author on the study. "In addition, specific proinflammatory genes are activated after the intake of glucose and a high-fat, high-carbohydrate meal, and these changes are observed in mononuclear cells that participate in vascular inflammation and insulin resistance," he says. ANI
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