Protein that triggers inflammatory responses in hemorrhage discovered
Washington: Researchers have discovered a protein in the human body that is capable of triggering and mediating inflammation in patients suffering from hemorrhage and sepsis.
Ping Wang, MD, director for the Laboratory of Surgical Research and head of the Center for Translational Research at the Feinstein Institute, and his colleagues discovered that a protein called cold-inducible RNA-binding protein (CIRP) is increased and released into the bloodstream in response to hemorrhagic shock and sepsis.
When CIRP triggers inflammation, it contributes to damage of organs in the body. Dr. Wang hypothesized that if CIRP activity is blocked, causing reduced inflammation, then patient survival will improve.
To test this theory, he and his colleagues observed that treatment with an antibody against CIRP significantly increased survival rates during hemorrhage and sepsis in preclinical studies.
Wang said that in this study, they identified a small peptide that can be potentially developed as anti-CIRP compound.
He said that they may have discovered a molecule that could be used in the future to treat hemorrhage and sepsis and save many lives.
The findings have been published online in journal Nature Medicine.
More from India
More from World
More from Sports
More from Entertaiment
- Vyapam Scam: IMA president Sudhir Tiwari fears life threat
- Vyapam Scam: Mystery over journalist Akshay Singh's death continues
- Jhansi police launches ‘Citizen Cop’ android app
- Panel discussion on RSS's 'Muslim Rashtriya Manch' first Iftaar party
- Kailash Vijayvargiya on Akshay Singh's death: Is a journalist bigger than me?
- Vyapam scam: MP medical college dean found dead in hotel, body sent for post-mortem
- Vyapam scam: Last rites of journalist Akshay Singh performed; MP CM assures of SIT probe
- Photographer captures International Space Station flying across moon
- PM Narendra Modi holds talks with Uzbek leader
- 'Selfie with daughter' controversy: Bollywood supports Shruti Seth