Protein that triggers inflammatory responses in hemorrhage discovered
Washington: Researchers have discovered a protein in the human body that is capable of triggering and mediating inflammation in patients suffering from hemorrhage and sepsis.
Ping Wang, MD, director for the Laboratory of Surgical Research and head of the Center for Translational Research at the Feinstein Institute, and his colleagues discovered that a protein called cold-inducible RNA-binding protein (CIRP) is increased and released into the bloodstream in response to hemorrhagic shock and sepsis.
When CIRP triggers inflammation, it contributes to damage of organs in the body. Dr. Wang hypothesized that if CIRP activity is blocked, causing reduced inflammation, then patient survival will improve.
To test this theory, he and his colleagues observed that treatment with an antibody against CIRP significantly increased survival rates during hemorrhage and sepsis in preclinical studies.
Wang said that in this study, they identified a small peptide that can be potentially developed as anti-CIRP compound.
He said that they may have discovered a molecule that could be used in the future to treat hemorrhage and sepsis and save many lives.
The findings have been published online in journal Nature Medicine.