Psychiatric disorders linked to protein involved in memory formation
London: A new study has linked psychiatric disorders have to a protein involved in the formation of long-term memories.
The study conducted by a team of scientists led by Alexei Morozov at the Virginia Tech Carilion Research Institute, has discovered a pathway by which the brain controls a molecule critical to forming long-term memories and connected with bipolar disorder and schizophrenia.
The mechanism - a protein called Rap1 - controls L-type calcium channels, which participate in the formation of long-term memories.
In the experiment, Morozov and colleagues knocked out the gene responsible for coding the enzyme Rap1, which he suspected played a role in activating L-type calcium channels.
The researchers then used live imaging techniques to monitor the release of neurotransmitters and electron microscopy to visualize L-type channels at synapses.
They discovered that, without Rap1, the L-type calcium channels were more active and more abundant at synapses all the time, increasing the release of neurotransmitters.
The results showed that Rap1 is responsible for suppressing L-type calcium channels, allowing them to activate only at the proper moments, possibly during long-term memory formation.
More from India
More from World
More from Sports
More from Entertaiment
- Terrorist outfit IS releases hitlist; 4000 people including 285 Indians targeted
- Mumbai: Woman missing after falling in manhole
- Mann Ki Baat: PM recalls dark days of 1975 Emergency, says democracy is our strength
- Mann Ki Baat: Conserve every drop of water, says PM
- PM Modi launches 'Smart City Project' in Pune
- Seven killed as car rams into minibus in Kenya's Kwale
- Hope law will be passed for construction of Ram temple by PM Narendra Modi-led government: VHP leader Pravin Togadia
- Rock stars and celebrities react with dismay to Brexit
- WATCH: How AAP MLA Dinesh Mohaniya was arrested by Delhi Police amidst high drama during press conference
- BJP president Amit Shah sounds poll bugle in Uttarakhand; slams Congress, Harish Rawat