Washington: A recent study has demonstrated that the A2b-type adenosine receptor, A2bAR, plays a significant role in the regulation of high fat, high cholesterol diet-induced symptoms of type 2 diabetes.The findings also identify A2bAR as a potential target for the treatment of type 2 diabetes.Katya Ravid, DSc/PhD, professor of medicine and biochemistry and director of the Evans Center for Interdisciplinary Biomedical Research at BUSM, led this study.Diets that are high in fat and cholesterol induce changes in how the body regulates blood glucose levels.Exercise induces an increased production adenosine, a metabolite produced naturally by cells. A2bAR, a naturally occurring protein receptor found in the cell membrane, is activated by adenosine.This receptor is known to play an important role in regulating inflammation, which is associated with type 2 diabetes and obesity.
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