Washington: The much touted naturally produced molecule called resveratrol, found in red wine, may help squeeze out diabetes, says a new study.In the study, resveratrol has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.
However, Coppari emphasized that his study does not support the conclusion that consuming products made from red grapes could alleviate diabetes."The main reason is that resveratrol does not cross the blood brain barrier efficiently," he said."In order for the brain to accumulate the same dose of resveratrol delivered in our study, the amounts of red wine needed daily would surely cause deleterious effects, especially in the liver. Rather, our study suggests that resveratrol``s analogs that selectively target the brain may help in the fight against diet-induced diabetes," he added.For the study, the researchers investigated what happens when resveratrol acts only in the brain. Specifically, they wanted to know whether resveratrol injected in the brain activated a group of proteins called sirtuins, which are found throughout the body and thought to underlie many of the beneficial effects of calorie restriction.In one group of animals, researchers injected resveratrol directly into the brain; another group received a saline-based placebo. All the surgically treated animals consumed a high-fat diet before and after the surgery.Coppari said the insulin levels of the animals treated with the placebo solution rose increasingly higher post-surgery."That``s a normal outcome because insulin sensitivity decreases the longer you keep an animal on a high-fat diet," he said.Insulin levels in the mice given resveratrol, however, actually started to drop and were halfway to normal by the end of the five-week study period, even though the animals remained on a high-fat diet.In addition, the researchers found that resveratrol did indeed activate sirtuin proteins in the brain. ANI
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