Paris: Scientists have uncovered a trio of genes tied to migraine headaches, including one in which the link is exclusive to women, according to a study published on Sunday.
Migraines are acutely debilitating headaches -- sometimes with an "aura", in which patients have the impression of seeing through frosted glass -- that strike up to 20 percent of the population.
Scientists describe the condition, which is three to four times more common in women, as a brain disorder in which neurons, or brain cells, respond abnormally to stimuli.
The precise cause it unknown, but inheritance is thought to play a significant role.
To assess the genetic component, Markus Schuerks of Brigham and Women`s Hospital in Boston coordinated an international sweep of genomes in 23,230 women, 5,122 of whom suffered from migraines.
So-called genome-wide association studies compare differences between individuals across the approximately three billion pairs of basic molecular building blocks found in the human genetic code.
The study, published today in the British journal Nature Genetics, is the largest to date of its kind. It found variations in three genes that showed up more frequently in migraine patients.
Two of them, known as PRDM16 and TRPM8, were specific to migraines, as opposed to other kinds of headaches.
TRPM8, in addition, was linked to migraines only in women. Earlier studies have shown that the same gene contains the genetic "blueprint" for a pain sensor, in both men and women.