Washington: Scientists have revealed that a single antibody shrank a variety of human tumours transplanted into laboratory mice, a pioneering research which may somedaypave the way for effective treatments for a number of cancers. A team at Stanford University School of Medicine says that the antibody works by masking a protein flag on cancer cells that protects them from macrophages and other cells in the immune system. The scientists achieved the breakthrough with human breast, ovarian, colon, bladder, brain, liver and prostate cancer samples. "Blocking this `don`t-eat-me` signal inhibits the growth in mice of nearly every human cancer we tested, with minimal toxicity. This shows conclusively that this protein, CD47, is a legitimate and promising target for human cancer therapy," said Prof Irving Weissman, who led the team.
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