Washington: A structural defect in skin cells can contribute to development of skin and food allergies, a new study has claimed.Northwestern Medicine and Tel Aviv University scientists` finding is linked to the team`s identification of a new rare genetic disease, called `severe dermatitis, multiple allergies, and metabolic wasting,` or SAM, caused by mutations in the molecule desmoglein 1.Kathleen Green, Joseph L. Mayberry, Sr., Professor of Pathology and Toxicology at Northwestern University Feinberg School of Medicine, said that Desmoglein 1 is best understood as the `glue` that holds the outer layer of human skin together.She said that the molecule was mainly believed to have a structural role: this adhesion between cells contributes to the physical barrier that regulates water loss and also acts as the body`s major defense against environmental elements.
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