Smart nanofibres to treat kidney failure
Tokyo: A new technique for purifying blood using a nanofibre mesh could be a cheap, wearable alternative to kidney dialysis, scientists say.
The nanofibre mesh for the removal of toxins from the blood was developed by researchers from the International Center for Materials Nanoarchitectonics (WPI-MANA).
The mesh may be incorporated into wearable blood purification systems for kidney failure patients. Kidney failure results in a build up of toxins and excess waste in the body.
Dialysis is the most common treatment, performed daily either at home or in hospital. However, dialysis machines require electricity and careful maintenance, and are therefore more readily available in developed countries than poorer nations.
Around one million people die each year worldwide from potentially preventable end-stage renal disease.
Mitsuhiro Ebara and co-workers at the International Center for Materials Nanoarchitectonics, National Institute for Materials Science in Ibaraki, Japan, have developed a way of removing toxins and waste from blood using a cheap, easy-to-produce nanofibre mesh.
The mesh could be incorporated into a blood purification product small enough to be worn on a patient's arm, reducing the need for expensive, time-consuming dialysis.
The team made their nanofibre mesh using two components: a blood-compatible primary matrix polymer made from polyethylene-co-vinyl alcohol, or EVOH, and several different forms of zeolites - naturally occurring aluminosilicates.
Zeolites have microporous structures capable of adsorbing toxins such as creatinine from blood.
The researchers generated the mesh using a versatile and cost-effective process called electrospinning - using an electrical charge to draw fibres from a liquid.
Ebara and his team found that the silicon-aluminum ratio within the zeolites is critical to creatinine adsorption. Beta type 940-HOA zeolite had the highest capacity for toxin adsorption, and shows potential for a final blood purification product.
Although the new design is still in its early stages and not yet ready for production, Ebara and his team are confident that a product based on their nanofibre mesh will soon be a feasible, compact and cheap alternative to dialysis for kidney failure patients across the world.
The study was published in the journal Biomaterials Science.