Washington: Early data from phase I trials of an HCV vaccine show encouraging results, with high immunogenicity and good safety profile.In the first study, a therapeutic T-cell vaccine, based on novel adenoviral vectors, was used on a small population of treatment naive patients with chronic genotype 1 HCV infection. Intra-muscular vaccination was administered 2 or 14 weeks into a 48-week course of treatment with Peg-IFNa2a/ribavirin.
Professor Heiner Wedemeyer, EASL``s Secretary General commented: "Vaccines are an exciting area of research now with the potential to add to the range of treatments available for patients with chronic viral hepatitis. These are early data but results are very encouraging indeed and as experts, we look forward to more scientific evidence being made available to support this new technology as a future treatment option as well as potentially preventing infection." Previous research and data shows that vaccination with adenoviral vectors induced highly potent and durable T-cell responses in healthy human and that similar vectors may prevent chronic infection in animals. This is the first time the immunogenicity and safety of vaccination was tested on HCV patients and healthy subjects.The data has been presented at the International Liver Congress. ANI
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