New York: An experimental supplement derived from soy may help postmenopausal women smooth their "crow`s feet" a bit, a small pilot study suggests.The supplement, known for now as SE5-OH, is under development by a Tokyo-based drug and supplement maker, Otsuka Pharmaceutical.It contains a compound called S-equol, which is made from fermented soy germ.The body can produce S-equol naturally, as a byproduct of digesting soy isoflavones, plant chemicals that are structurally similar to estrogen. S-equol itself is believed to attach to estrogen receptors on body cells, and may have weak estrogen-like effects.Skin cells are among those that have estrogen receptors, and it`s thought that women`s waning estrogen levels after menopause may contribute to skin aging.So for the new study, researchers at the Japanese company looked at whether giving postmenopausal women S-equol supplements might improve the appearance of crow`s feet -- those lines that begin to surface at the outer corners of the eyes sometime in middle-age, or earlier.The researchers, led by Ayuko Oyama, randomly assigned 101 postmenopausal Japanese women to one of three groups: one that took a higher dose of the S-equol supplement (30 milligrams) every day for 12 weeks, one that took a lower dose (10 mg) and one that took placebo tablets containing only starch.
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