London: New drug that lowers levels of ‘bad cholesterol’ by up to two-thirds after 12 weeks could one day be used as an alternative treatment for patients who do not respond well to other treatments like statins, researchers have suggested.The drug, called AMG 145, is currently only being tested in an injectable form but scientists hope to be able to make it available as a pill in the future, the Telegraph reported.The jab works by helping the body use up ‘bad’ low-density lipoprotein (LDL) cholesterol at a faster rate than normal, clearing blood vessels of the substance. By contrast, statins work by slowing production of LDL.A trial of 631 patients with high cholesterol who were already on statins found a fortnightly jab of a 145mg dose lowered their LDL levels by 66 per cent after 12 weeks, compared to those given a placebo. In absolute terms, LDL cholesterol fell by just over 2.0 mmol per litre.“The observed reductions in LDL cholesterol are extraordinary, especially when one considers that they are seen on top of statin therapy,” the paper quoted Dr Robert Giugliano, from the Brigham and Women’s Hospital in Boston, Massachusetts, as saying.
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