London: Stem cells derived from a patient with an inherited heart disease could help test specific treatments for the disease, known as long QT syndrome, say scientists.Researchers from the Technion-Israel Institute of Technology turned the skin cells into a type of all-purpose stem cell called induced pluripotent stem cells, or iPSCs. Prof. Lior Gepstein then coaxed these stem cells — which have the capability to become any cell type in the human body — to become cardiac cells. The newborn heart cells showed an abnormal electrical activity in the laboratory, recapitulating clinical presentation of the long QT syndrome patient, making them useful for studying this potentially lethal disorder.The research team was then able to test several types of drugs to find out how they might aggravate or alleviate long QT symptoms in the cells.The study can help scientists learn more about how a disease like long QT syndrome works at the cellular level, Gepstein said.
Some patients acquire the disorder after taking certain medications, but the disease is also caused by an array of inherited genetic defects that affect the proteins involved in recharging the heart.In the study, Gepstein and colleagues used skin cells from a 28-year old woman with type-2 LQTS, which is caused by a single genetic mutation.The results appear in the January 16 issue of the journal Nature. ANI
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