Washington: In two groundbreaking studies, doctors have used stem cells from bone marrow to help heal children with a killer skin disease, and to repair injured lungs. Researchers led by University of Minnesota doctors John Wagner and Jakub Tolar used bone marrow stem cells to treat children with a rare genetic skin disorder called recessive dystrophic epidermolysis bullosa (RDEB).
"Their skin is better, they are more active, they use fewer bandages, they have donor cells in their skin and we have been able to show that they produce the all-important collagen 7 in their skin," he said. Collagen 7, a protein that keeps layers of skin "glued" to each other and to the body, is missing in EB sufferers. Although the children still have residual wounds on their skin, which means they have not been cured of their chronic illness, Tolar said the treatment had given them a new lease on life. "They`re eating, moving around, one of them bought a trampoline, they eat chips. These things were unheard of before the transplant," he said. Since 2007, Wagner and Tolar have used transplanted bone marrow containing healing stem cells to treat 12 children with the most aggressive forms of epidermolysis bullosa. All of the children have responded to the therapy, to varying degrees, the study, published in the New England Journal of Medicine, said. In a separate study, reported in the Journal of Biological Chemistry, researchers at the University of California, San Francisco (UCSF) used bone marrow stem cells to treat acute lung injury, one of the most common causes of respiratory failure in hospital intensive care units. A team led by Michael Matthay and Jae Lee at the Cardiovascular Research Institute of UCSF re-created unhealthy lung conditions in the lab by culturing human alveolar cells and then chemically causing inflammation. They then added bone marrow stem cells to the mix and observed how things changed. "What happens in lung injury is that the membrane becomes very porous, fluid comes into the lung and pulmonary edema occurs, which leads to a worse outcome," Lee said. "We found that if you add stem cells, there`s a restoration of the permeability, meaning stem cells were protective -- they prevented permeability-increase in the epithelium," he said. The authors of the UCSF study say the findings are the first to demonstrate how certain marrow bone stem cells restore the border of the lungs. They hope to begin phase II clinical trials to prove the therapy is viable for preventing respiratory failure in critically ill patients. Both of the studies used adult stem cells, not embryonic stem cells which have stirred controversy among the religious right in the United States and the Vatican. The Obama administration last year lifted a ban on the use of embryonic stem cells in scientific research that had been imposed by the administration of George W. Bush. Embryonic stem cell research is controversial because human embryos are destroyed in order to obtain the cells capable of developing into almost every tissue of the body. But it also holds great promise for treating cancer, diabetes, Alzheimer`s and other diseases and even growing organs and tissues for transplants. Bureau Report
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