Washington: A missing link between the body’s biological clock and sugar metabolism system has been discovered, which may help avoid the serious side effects of drugs used for treating asthma, allergies and arthritis.Scientists at the Salk Institute for Biological Studies found that proteins that control the body’s biological rhythms, known as cryptochromes, also interact with metabolic switches that are targeted by certain anti-inflammatory drugs.The finding suggests that side effects of current drugs might be avoided by considering patients’ biological rhythms when administering drugs, or by developing new drugs that target the cryptochromes.“We knew that our sleep and wake cycle are tied to when our bodies process nutrients, but how this happened at the genetic and molecular level was a complete mystery,” said Ronald M. Evans, a professor in Salk’s Gene Expression Laboratory, who led the research team.“Now we’ve found the link between these two important systems, which could serve as a model for how other cellular processes are linked and could hold promise for better therapies,” he explained.
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