Washington: Researchers including one of Indian origin, have made a discovery that sheds light on why the human body is unable to adequately fight off HIV infection.The researchers discovered that the viral protein vpu, which is created by HIV during infection, directly interferes with the immune response protein IRF3 to dampen the ability of the immune system to protect against virus infection.“By understanding exactly what HIV does to hamper the innate immune response during early infection, we can develop a clearer picture of how the virus is able to evade immunity to establish a long-term infection,” said Dr. Brian Doehle, a postdoctoral fellow and lead author of the article.The research expanded on an earlier discovery by the Gale lab that HIV directly antagonizes the early innate immune response in infected cells by impairing IRF3 function.
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