World`s first human `heart shrinking` trial next week in UK

Last Updated: Sunday, April 29, 2012 - 12:50

London: British surgeons are all set to conduct next week the world`s first "heart shrinking" trial in humans aimed at combating cardiac failure.

The technique will involve electrically stimulating one of the nerves leading to the heart, which it is hoped could shrink the heart and improve life expectancy, says a team at the Liverpool Heart and Chest Hospital and The Royal Liverpool University Hospital.

In fact, the first patient will be operated on next week, after the technique was shown to keep rats and dogs alive for longer, the `BBC` reported.

As the heart loses its ability to pump, it fills with too much blood and becomes stretched over time. The more the heart enlarges, the worse the symptoms. So, surgeons hope to reverse the damage.

They will fit a device -- similar to a pacemaker -- to the vagus nerve which runs to the heart. Surgeons say that the electrical stimulation should "protect the heart" from the effects of the hormone adrenaline.

Adrenaline makes the heart pump harder and faster; this is one of the body`s responses to heart failure -- but doctors say it becomes toxic over time and damages the heart further. The idea is that by shielding the heart, it`ll stop enlarging and begin to shrink, say the surgeons.

Dr Jay Wright, a consultant cardiologist at Liverpool Heart and Chest Hospital, said: We`re hoping it will shrink the heart, but it might not be to normal size."

He said shrinkage "would lead to improvement in symptoms -- we know that the bigger the heart the worse the symptoms".

Nearly 100 patients will take part in the trial at 30 hospitals around the world. The first will be Carl Jordan, who used to be a paramedic. He has had several heart attacks which have damaged his heart, causing it to become enlarged.

He said: "Being the first person to have this device implanted in Liverpool was a huge decision. My quality of life at the moment is not great, because of the restrictions my condition has imposed on me, especially the breathing problem, as some days this is quite severe and getting worse."

PTI



First Published: Sunday, April 29, 2012 - 12:50

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