World’s first lab-grown kidney implanted into rat
Zee Media Bureau
Washington: In a step that may aid scientist to get closer to being able to grow kidneys for humans, researchers at Massachusetts General Hospital in Boston, USA, have created a kidney in the laboratory, which works successfully when implanted into animals.
The bio-engineered rat kidneys successfully produced urine both in a laboratory apparatus and after being transplanted into living animals.
The team describes building functional replacement kidneys on the structure of donor organs from which living cells had been stripped, an approach previously used to create bio-artificial hearts, lungs and livers.
The research, published in the journal Nature Medicine, involves kidneys of recently deceased rats and detergent, which is used to strip away the cells, leaving behind the underlying scaffold of connective tissues such as the structural components of blood vessels. They then regenerated the organ by seeding this scaffold with two cell types - human umbilical-vein cells to line the blood vessels, and kidney cells from newborn rats to produce the other tissues that make up the organ.
"What is unique about this approach is that the native organ`s architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient`s vascular and urinary systems," said Harald Ott, of the MGH Center for Regenerative Medicine, senior author of the study.
"If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells," Ott said.
According to medical experts, around ten per cent of Indian adult suffer from chronic kidney diseases and nearly two lakh patients require dialysis or kidney transplant every year. However, due to lack of organs availability, only 5,000 undergo a transplant.
More from India
More from World
More from Sports
More from Entertaiment
- One year of Modi govt: PM promises to fulfil aspirations
- Watch: Mumbai cops find new secret agents in housewives!
- Hundreds die as heat wave continues in India
- 2G scam: Ex-TRAI chief alleges Manmohan Singh had warned him to cooperate
- Pranab Mukherjee defends Bofors scam, says it was just a media trial
- Salman Khan attends sister Arpita's wedding reception in Mandi
- Zee Media's mega survey on Modi govt
- Zee Media Exclusive: Vidya Balan chats about 'Hamari Adhuri Kahani'
- Para athlete Deepa Malik complains of callous service by Air India
- I eat beef, can somebody stop me?: Kiren Rijiju hits back at Naqvi
- Smriti Irani visits Amethi, promises to pay insurance money to 25,000 women
- Delhi: Visually impaired boy scores 91.4% in CBSE 12th Board exams
- One year of Modi govt: Amit Shah addresses media
- MP: 14-year-old boy works as bonded labour since 2009
- UP: Man chops off wife's nose, hair for dowry
- One year of NDA govt: PM Modi writes open letter to nation, promises to transform India
- Arpita-Aayush wedding reception: Salman Khan spreads love in Mandi, says `hum aapke hain`
- World optimistic about India: PM Narendra Modi on 1 year of NDA govt
- MSBSHSE Class 12th HSC results 2015 to be declared at 1pm tomorrow
- CBSE Class 10 Board Result 2015 (cbse.nic.in, cbseresults.nic.in) postponed?
- CBSE Class 10 Board Result 2015 to be announced on May 28
- Rahul Gandhi takes a dig at one year of Modi govt, wishes 'happy birthday' to 'suit-boot ki sarkar'
- Check mahresult.nic.in for MSBSHSE Maharashtra Class 12 HSC Result 2015
- Bharatiya Janata Party lacks majority for Ram Temple, Article 370: Amit Shah
- AAP govt moves resolution against MHA notification: As it happened
- Maharashtra MSBSHSE HSC Result 2015 on mahresult.nic.in
- Heatwave kills 90 more in Andhra, Telangana; toll crosses 800
- I was misquoted, says Kiren Rijiju on 'beef' remark
- Gujjars adamant on holding talks in Bayana; rail tracks remain blocked
- CBSE 10th result to be declared tomorrow