Fruits, veggies could harbour cure for deadly skin cancer
Washington: Gossypin, a naturally-occurring substance found in fruits and vegetables, has been for the first time found effective against melanoma, which causes the majority of deaths from skin cancer.
For the first time, scientists have demonstrated the mechanism of action of gossypin, a naturally-occurring substance found in fruits and vegetables, as a treatment for melanoma, which causes the majority of deaths from skin cancer.
Texas Biomed`s Hareesh Nair, Ph.D, stated that they identified gossypin as a novel agent with dual inhibitory activity towards two common mutations that are the ideal targets for melanoma treatment.
At the moment, there is no single therapeutic agent or combination regimen available to treat all melanomas, of which about 76,000 new cases are diagnosed annually, according to the American Cancer Society.
"Our results indicate that gossypin may have great therapeutic potential as a dual inhibitor of mutations called BRAFV600E kinase and CDK4, which occur in the vast majority of melanoma patients. They open a new avenue for the generation of a novel class of compounds for the treatment of melanoma," Nair added.
Nair and his colleagues found that gossypin inhibited human melanoma cell proliferation, in vitro, in melanoma cell lines that harbor the two mutations.
Gossypin stunted activities of the mutated genes, possibly through direct binding with them. It also inhibited the growth of various human melanoma cells.
In addition, gossypin treatment for 10 days of human melanoma cell tumors with the mutations transplanted into mice reduced tumor volume and increased survival rate.
Further studies are planned by Nair`s team to understand how the body absorbs gossypin and how it is metabolized.
Their finding appeared recently in the journal Molecular Cancer Therapeutics.
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