How Vitamin D reduces inflammations discovered
Washington: Specific molecular and signaling events have been discovered by which Vitamin D inhibits inflammation, researchers claim.
Scientists showed in their experiments that low levels of Vitamin D failed to inhibit the inflammatory cascade, while levels considered adequate did inhibit inflammatory signaling.
“This study goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation,” said study lead author Elena Goleva, assistant professor of pediatrics at National Jewish Health.
“Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient, may benefit from vitamin D supplementation to get their serum vitamin D levels above 30 nanograms/millilitre,” she said.
Researchers examined the specific mechanisms by which vitamin D might act on immune and inflammatory pathways. They incubated human white blood cells with varying levels of vitamin D, then exposed them to lipopolysaccharide (LPS), a molecule associated with bacterial cell walls that is known to promote intense inflammatory responses.
Cells incubated with no vitamin D and in solution containing 15 ng/ml of vitamin D produced high levels of cytokines IL-6 and TNF-alpha, major actors in the inflammatory response. Cells incubated in 30 ng/ml vitamin D and above showed significantly reduced response to the LPS. The highest levels of inflammatory inhibition occurred at 50 ng/ml.
Through a complex series of experiments, the researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene known as MKP-1. MKP-1 interferes with the inflammatory cascade triggered by LPS, which includes a molecule known as p38, and results in higher levels of IL-6 and TNF-alpha.
The results of the study were reported in the March 1, 2011, issue of The Journal of Immunology.
More from India
More from World
More from Sports
More from Entertaiment
- Jamaat-e-Islami chief announces Rs 100 cr reward for PM Modi's arrest
- DNA: Captain Saurabh Kalia's torture at the hands of Pakistani Army
- DNA: Govt tests Maggi noodle samples from all states
- Zee Media exclusive interview with victim of Uber molestation
- Jamaat-e-Islami chief announces Rs 1 billion reward for PM Modi's arrest
- Was asked to call Sunanda Pushkar’s death `natural`: AIIMS doctor
- From being the ‘Dabangg’ girl to ‘Akira’ - Sonakshi Sinha’s journey so far
- Maggi row: Delhi registers case against Nestle, Kerala withdraws stock from govt stores
- China ship carrying 458 on board sinks in Yangtze River: Five dead, hundreds missing