Washington: Scientists have found that a 12-week treatment of the fermented soy germ-based nutritional supplement containing S-equol significantly lowered hemoglobin A1c (HbA1c), LDL cholesterol and improved vascular stiffness, all factors that occur as part of metabolic syndrome.S-equol [7-hydroxy-3-(4’-hydroxyphenyl)-chroman] is a compound resulting -- when certain bacteria are present in the digestive tract -- from the natural metabolism, or conversion, of daidzein, an isoflavone found in whole soybeans.Not everyone can produce S-equol after soy consumption, as the production depends on the types of bacteria present in the large intestine and may be influenced by the amount of soy consumed.“This study is the first to provide evidence that a daily supplement of soy-based S-equol favourably change metabolic syndrome risk factors, particularly in women. Because not all individuals have the ability to produce S-equol naturally after eating soy, the study results are very interesting and warrant examination in future studies,” said Belinda H. Jenks, Ph.D., co-author of the study and director of Scientific Affairs and Nutrition Education at Pharmavite LLC, an U.S. subsidiary of Otsuka Pharmaceutical Co, Ltd, which sponsored the study.Development and ongoing research of a supplement containing S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd.About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, have the ability to produce S-equol. Research indicates that Japanese women have milder menopausal symptoms in those who are S-equol producers compared to nonproducers.Pharmavite LLC, the makers of Nature Made vitamins and minerals and a subsidiary of Otsuka, is studying the supplement for the management of menopausal symptoms.
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