Genetic markers for breast cancer identified
Washington: Innovative studies have explored a number of promising pathways for treatment and new targets for preventing the spread of breast cancer.
In these studies, a multidisciplinary approach was applied to analyse the molecular basis of breast cancer bone metastasis, combining tools to analyse genomic information with animal models and clinical analysis of cancer metastasis.
Candidate genes, including one dependent on EGFR 3 (Epidermal Growth Factor Receptor), and a TGFb (Transforming Growth Factor-beta) target gene called Jagged1 were identified.
The study revealed a network of molecular crosstalk between tumour and bone cells using Jagged1 in tumour cells, EGFR in bone cells and TGFb released from damaged bone.
Such pathological tumour-host tissue interactions eventually lead to tumour expansion and bone destructions.
Targeting these pathways can reduce the development of bone metastasis and provide new avenues for managing the progression of the disease to the bones.
“We are excited to have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional potential targets for preventing and treating the disease,” said Dr. Yibin Kang of Princeton University.
They studies will be presented this week at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program.
More from India
More from World
More from Sports
More from Entertaiment
- Pakistan had achieved nuclear capability in 1984: Abdul Qadeer Khan
- Pakistan able to target Delhi from Kahuta near Rawalpindi in five minutes: Dr Abdul Qadeer Khan
- US zoo kills gorilla after 3-year-old boy falls into enclosure
- EC cancels polls for two remaining Tamil Nadu Assembly seats - Know why
- Cloudbursts, rainfall in Tehri district of Uttarakhand; Gangotri-Kedarnath road closed, pilgrims stranded