Washington: High doses of drugs aimed at lowering cholesterol are linked to increasing numbers of new diabetes cases in patients, said a review of multiple studies on the topic published Tuesday.However, those same high doses helped dramatically lower the incidence of cardiovascular problems in patients, leaving doctors to balance the benefits and risks according to each individual patient.The meta-analysis compared high and moderate doses of the anti-cholesterol drugs known as statins, in five randomized clinical trials on 32,752 people, and was published in the Journal of the American Medical Association.Over an average follow-up period of nearly five years, 8.4 percent of the patients developed diabetes -- 1,449 in the intensive-dose category and 1,300 in the moderate dose group -- a total of 149 more in the higher dose group.But when the researchers examined how many patients had major cardiovascular problems after therapy, they found the higher dose statin group had 416 fewer such events (3,134 in the intensive group and 3,550 in the moderate one).
The drugs help reduce the risk of heart attack and stroke by lowering a person`s low-density lipoprotein (LDL), sometimes known as "bad cholesterol."Earlier this month, the US Food and Drug Administration issued a warning about high doses of the cholesterol-lowering medication simvastatin (Zocor, Vytorin, Simcor) because of an elevated risk of muscle injury associated with the 80 milligram dose, particularly in the first year of treatment.Bureau Report
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