Washington: People with HIV who take antiretroviral drugs before their health declines have a 96 percent lower risk of transmitting the virus to a partner, according to a breakthrough global study.
There were 27 HIV transmissions in the delayed group that could be traced directly to the infected partner, a difference the study described as "highly statistically significant."National Institute of Allergy and Infectious Diseases chief Anthony Fauci hailed the findings."Previous data about the potential value of antiretrovirals in making HIV-infected individuals less infectious to their sexual partners came largely from observational and epidemiological studies," said Fauci."This new finding convincingly demonstrates that treating the infected individual -- and doing so sooner rather than later -- can have a major impact on reducing HIV transmission."According to Wafaa el-Sadr, a member of the executive committee of the HIV Prevention Trials Network (HPTN), the group that did this study, the results should have a major impact on treatment guidelines."I think HPTN 052 will always be recognized as a landmark study that truly may transform treatment as well as prevention of HIV globally," she told AFP.Sadr, who is also a professor of medicine and epidemiology at Columbia University in New York, said the couples in the study would continue to be followed."Everybody who was not offered immediate treatment is now being offered immediate treatment, now that we know what we know," she said. The study was initially set to continue until 2015 but the independent safety and monitoring board halted the randomization phase early "because of the very clear and remarkable benefits that were shown," she said. "They determined that these findings were so profoundly important that they had to be shared immediately," she said. Executive Director of the Joint United Nations Program on HIV/AIDS (UNAIDS), Michel Sidibe, described the study as "a game-changer" that "will drive the prevention revolution forward." AIDS has claimed more than 25 million lives and more than 60 million people have become infected with the human immunodeficiency virus (HIV) since the first deaths from the disease were recorded in 1981. Around 80 percent of new infections occur through sex, according to UN figures. Antiretroviral treatment, first devised in the 1990s, is a combination of drugs that can reduce the level of virus in the blood to below detectable levels. But it can also have distressing side-effects such as diarrhea, nausea, vomiting and weight loss. Designed primarily as a treatment, antiretrovirals are now being tested for prevention, as a pill taken by gay men at risk of unsafe sex and as a vaginal gel for women. Early data from these trials is encouraging.Bureau Report
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