Washington: Scientists have reported findings showing new evidence about broadly-reactive neutralising antibodies, which block HIV infection.Leo Stamatatos of the Seattle Biomedical Research Institute said the major stumbling block in the development of an effective vaccine against HIV is the inability to elicit, by immunisation, broadly reactive neutralising antibodies (NAbs).
He said these antibodies target only a few regions of HIV, which is good from the standpoint of vaccine development.In addition, the new findings have shown that these antibodies are generated much sooner than previously thought, in some cases as soon as a year after infection."These studies provide a strong rationale to begin teasing out the early immunological signals that allow some individuals, but not others, to mount broadly reactive neutralising antibody responses," added co-author Galit Alter.The findings were published in the journal PLoS Pathogens. ANI
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